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& Dib, S
GLP-1 is a naturally occurring hormone involved in appetite and blood sugar regulation
Unlike semaglutide which solely activates GLP-1R (one of the three pivotal receptors regulating glucose homeostasis), tirzepatide also activates glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) to enhance metabolic benefits with reduced side-effects 5
Regular HbA1c monitoring (typically every 36 months) provides the most reliable assessment of long-term glucose control and medication effectiveness
See primers in Table S8
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