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In terms of renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria and not on hard kidney endpoints [3, 6, 8]

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SUSTAIN 6 was primarily focused on cardiovascular outcomes but also observed weight management as a secondary outcome

Additional studies have explored activation of focal adhesion kinase (FAK) and paxillin pathways in fibroblasts, which are involved in cellular migration, extracellular matrix interactions, and structural tissue dynamics [2]