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Most reported adverse events are local irritation or contact dermatitis, generally mild and self-limited
Clostridium butyricum has a documented history of use as a probiotic, particularly in Asian and European markets where it has been commercially available for decades
Reduced glutathione availability has been associated with increased thyroid peroxidase (TPO) antibody levels and Hashimotos thyroiditis progression
Avoid taking with grapefruit juice or high-fat meals unless specifically directed
Figure 1 Furthermore, SAM serves as a methyl donor, methylating DNA and proteins, including histones (Zade et al., 2023), which in turn influences epigenetic regulation, and gene expression ( Figure 1 )
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