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Phase I and II clinical trials conducted have shown improved cognitive and motor function with different drugs from GLP-1RA group although the small sized and limited duration of trials have not provided a conclusive result to influence the practice, although with further advancement in ongoing trials effects observed may be noteworthy for intervention in future practice (119)

It assists with weight loss by helping you stay energized but keeping you feeling full for longer, so you eat less

In fact, in the aforementioned trials most patients received appropriate treatment for HF, including ACE-i or ARBs

Safety Considerations When Combining Metformin with GLP-1 Therapy The primary safety consideration involves gastrointestinal side effects, which occur more frequently when GLP-1 medications are introduced, particularly nausea and constipation during dose escalation phases

Seek advice if you experience: Severe or persistent stomach pain or cramping Repeated vomiting or difficulty keeping fluids down Unexplained or rapid weight loss Fever, chills, or signs of dehydration Blood in stools or black, tar-like stools Symptoms that continue for several weeks without improvement These symptoms may suggest an underlying digestive issue that requires further assessment