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The regulatory environment has changed multiple times since 2024 and can change again

After applying OPSW, all clinicodemographic characteristics of patients in the GLP-1RA versus insulin cohorts were well-balanced with a standard difference of less than 0.1 set as the threshold (Table 1 & Supplementary Table 1)

The number of discussions increased substantially over time, with greater than 95% of discussions taking place after January 1, 2022

Improved Glycemic Control Studies show Semaglutide may: Enhance insulin secretion Reduce glucagon release Improve fasting and postprandial glucose stability 3