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In women, it often develops on the lower legs
On the other hand, mitochondria can effectively reduce ETC-derived ROS by activating uncoupling proteins, which lower the inner membrane potential a key driver of ROS production, thereby preserving cellular redox homeostasis [142]
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103 Moreover, GCGR is expressed in the liver and shows direct hepatic benefits, including a reduction in lipid content and an increase in metabolic expenditure
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