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Most patients (provided they are lean) will be able to put a subcutaneous needle VERY close to the muscle (if not inside) depending on the site they use for the injection

Unlike fat-soluble vitamins that accumulate in body tissues, water-soluble vitamins are generally excreted through urine when consumed in excess

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Rotate injection sites frequently (e.g., abdomen, thighs, upper arms) to prevent local irritation and lipohypertrophy

However, for older people or those already deficient in B12, higher dosages may be necessary because lack of intrinsic factor-mediated absorption requires absorption by passive diffusion from the gut