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Administered at a dose of 360 mg/kg for 14 days, the extract markedly reduced IBA-1, IL-1, A1-42, and phosphorylated tau (p-tau) levels, highlighting its anti-inflammatory and neuroprotective properties (Wang Y
384 A synthetic curcumin analog (C1) similarly activates TFEB and reduces amyloid- and tau pathology in AD models
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The timeline for potential benefits in humans has not been established through clinical trials
The second step involves the Schiff base intermediate being protonated, which is done by the transfer of a hydride ion from NADPH resulting in L -glutamate
