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In the ATTAIN-1 trial of orforglipron, the most common adverse events were nausea (2133% depending on dose), constipation (2129%), diarrhea (2123%), vomiting (1324%), and heartburn

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The mean body mass index (BMI) was 28 kg/m2

Natalie Rasgon, MD, PhD, professor of psychiatry and behavioral sciences at Stanford, described the findings as "an exciting addition to our understanding of the mechanisms of depressive illness." "As a clinical psychiatrist, I have treated many people with this disorder in my practice," she said