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Two studies were related to drugdrug interactions, 2 were related to drugfood interactions, and 3 were relevant to drug-dosing condition interactions of semaglutide
The counterargument is that SGLT-2i probably has a stronger case in relation to cardiovascular protection, particularly reduction in heart failure hospitalization, but these agents can be problematic in those with urinary tract pathologies or significant renal impairment
It also contains large quantities of cysteine
Patient-specific risk factors include: Personal or family history of nephrolithiasis : Individuals with prior kidney stones have a recurrence rate of approximately 50% within 510 years, making this the strongest predictor of future stone formation
Finally, also the finding of unchanged values of APRI and FIB4 scores under semaglutide therapy was not surprising
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