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On the other hand, GLP-1 RA can reduce epicardial fat and semaglutide 2.4 mg have shown to improve physical function and symptoms in people with HFpEF [93]

Initial Treatment Phase Starting semaglutide involves an initial phase where the dosage is gradually increased to minimize potential side effects such as nausea and gastrointestinal discomfort

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Common adverse effects associated with probiotic use are typically mild and gastrointestinal in nature: Bloating and gas, especially during the first few days of use Abdominal discomfort or cramping Changes in bowel habits (diarrhea or constipation) Nausea (less common) These symptoms usually resolve within one to two weeks as the gut microbiome adjusts