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[6] Factors that may prolong or worsen symptoms include: Rapid dose escalation beyond what the individual gut can tolerate High-fat, high-sugar, or heavily processed dietary intake Concurrent use of medications that can independently cause loose stools, such as metformin, magnesium-containing preparations, or orlistat a clinician should review the full medication list if diarrhoea is persistent Underlying gastrointestinal conditions such as inflammatory bowel disease or coeliac disease Real-world duration of symptoms may differ from controlled trial settings
Local cortisol worsens insulin resistance
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