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Generic tirzepatide medications would drastically reduce costs, ease global shortages, and drive wider adoption of dual-agonist therapies (targeting both GLP-1 and GIP receptors), resulting in greater HbA1c reduction and weight loss overall, she told Healthline

Target the middle third of the thigh, staying at least four inches above the knee and four inches below the hip

A comprehensive medical history is essential to identify contraindications, including personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, as GLP-1 agonists carry a boxed warning regarding thyroid C-cell tumors observed in rodent studies

The case for long-term treatment An increasing number of medical professionals view GLP-1 therapy as a long-term or permanent treatment for obesity, similar to how statins are used long-term for cholesterol management or blood pressure medications are used indefinitely for hypertension

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