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Its extended half-life allows prolonged receptor interaction compared to native IGF-1

The system works as follows: regenerative silk fibroin nanofiber hydrogels, carrying the nanorobots, are activated by NIR to actively move deep into the bone metastasis microenvironment, release thrombin to induce local microvascular embolization, and simultaneously use gold nanorods for photothermal therapy

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UV radiation accelerates peptide degradation, reducing potency over time

As shown in this review, most reported literature on GSH transporter targeted brain drug delivery systems was developed based on the use of GSH-PEG compared with the diverse ligands available for the transferrin receptor, LDL-receptor and glucose transporter