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Interestingly, OB GLP-1 signalling is also activated in metabolic stress states, such as obesity and insulin resistance, with an improvement of glucose homeostasis due to increased insulin secretion as shown in our data from obese WD mice
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The dual action of Tirzepatide effectively reduces caloric intake while improving glucose metabolism, which explains why the SURMOUNT-1 trial data showed up to a 22.5% mean weight reduction at the 72-week mark
The significant impact of GLP-1RAs on calcium homeostasis and cellular behavior is also confirmed in other cell types apart from RGCs
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