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DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks

Cardiovascular Benefits : The SELECT trials demonstration of cardiovascular risk reduction in non-diabetic obese patients represents a paradigm shift, establishing GLP-1 agonists as potentially life-saving interventions beyond weight loss

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Junto con otras estrategias como la terapia antiplaquetaria (en pacientes con ECV o alto/muy alto riesgo), la presin arterial y la reduccin de lpidos, los cardilogos no deben perder la oportunidad de implementar terapias basadas en terapias para reducir el riesgo cardiovascular que en definitiva es el objetivo primario del tratamiento y control de nuestros pacientes

Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors