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Gp120, Tat, Vpr, and Nef are actively secreted by infected cells during HIV-1 infection, even in the presence of effective ART [34]

Iron overload is closely related to insulin resistance, decreased glucose tolerance, and the occurrence of diabetes mellitus

In ACCESS II, across all active arms in participants who reached doses 120 mg or higher from 28 to 44 weeks, there was only one (3.7%) adverse event (AE)-related treatment discontinuation

Others may develop symptoms later, especially after dose increases

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