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But often, the root cause of GI upset when taking GLP-1s is due to changes in gut motility, particularly delayed gastric emptyingwhich is the slowed rate at which food leaves the stomach and enters the small intestine

For most people, the drug doesnt come with fussy rules about when it should be taken

The peptide also affects collagen synthesis genes and inflammatory response genes

SNAC was generally rapidly absorbed and eliminated, with no measurable exposure after approximately 46 h

Research shows that the bulk of retatrutide's effects are driven by loss of fat mass that is probably the result of a larger and more prolonged reduction in food intake compared to similar peptides[2]