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These findings shed light on mechanisms underlying 5FU resistance and propose a rational strategy for combination therapy in CRC, emphasizing the potential clinical benefit of targeting mitochondrial metabolism to overcome resistance and enhance patient outcomes

(2003, Bulletin of Experimental Biology and Medicine) showed Epithalon activated telomerase in human somatic cells in vitro, which generated significant interest

In contrast, nitro-benzyl-glutathione, a GSH analog in which the thiol group is protected, and GSSG, did not elicit this effect

Glutathione serves as the bodys "master antioxidant"a critical molecule for cellular defense and repair

Each has different properties, different bioavailability, and different roles in the body