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Additionally, a double-blind, parallel-group, placebocontrolled trial (considered the gold standard in clinical research) was conducted on 50- to 80-year-old Japanese individuals diagnosed with mild cognitive impairment to examine the efficacy of oral administration (3 gms/day mycelial powder) of Lions Mane ( Hericium erinaceus ) [13] The Lions Mane group showed significantly increased scores on the cognitive function scale compared with the placebo group at weeks 8, 12, and 16 of the trial