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MOTS-c is also contraindicated for people who take AMPK-activating medicines, such as metformin , thiazolidinediones , and aspirin , as well as anyone with an active cancer diagnosis and people who are pregnant or breastfeeding

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This depends on the severity of symptoms, B12 levels, and overall health

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Taking cyanocobalamin if you have a methylation issue or MTHFR defect (3) in your genes can also cause issues as your body attempts to methylate the B12 before it can utilize it completely

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