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The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells
The 5 mg vial (+ 3 mL bacteriostatic water) Worked out step by step at the documented 100 mcg dose (remember 100 mcg = 0.1 mg): Concentration: 5 mg 3 mL = 1.67 mg/mL Draw volume: 0.1 mg 1.67 mg/mL = 0.06 mL Units: 0.06 mL 100 = 6 units The 10 mg vial (+ 3 mL bacteriostatic water) Same diluent volume, double the powder, so the solution is twice as concentrated and the same dose occupies half the volume: Concentration: 10 mg 3 mL = 3.33 mg/mL Draw volume: 0.1 mg 3.33 mg/mL = 0.03 mL Units: 0.03 mL 100 = 3 units This is the single most important thing to internalize: the same 100 mcg dose is 6 units from a 5 mg vial but only 3 units from a 10 mg vial
Intracellularly, Gln can be converted by GLS1/GLS2 into glutamate, which is subsequently metabolized by GLUD or through transamination reactions to generate -KG that enters the TCA cycle, thereby providing anaplerotic substrates for oxidative metabolism and supporting mitochondrial OXPHOS activity (58)
However, oral routes expose them to gastric acid, bile, enzymes, and microbial competition, often reducing survival to under 10%
Glutathione acts as a detoxifier and boosts the immune system
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