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However, when combined with a sulfonylurea (which forces insulin out regardless of glucose), the combo can cause lows

They are not interchangeable with or categorically comparable to Lipo-B or Lipo-C formulations

Nat Rev Endocrinol (2011) 8(3):16071

Safety Considerations: When You Should NOT Change Your Injection Day Without Provider Input If you're in your first 12 weeks of treatment (dose escalation phase), injection day changes should be minimal and provider-approved

Those things now, the data shows that thats not necessarily the case, but we still caution because theres a risk of increased depression in vulnerable patients and there can be suicidal ideation