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High-risk indicators include: Marketing that references weight loss, diabetes, or clinical outcomes Sales to non-research customers High sales volume inconsistent with research use Distribution channels that mirror consumer or medical supply chains Even without explicit marketing claims, the surrounding context can trigger enforcement

GLP-1 in addiction medicine: GLP-1 acts on pancreas, gut, kidney, heart and thyroid receptors to activate reward/stress hubs (VTA, NAc, ARC, PFC, hypothalamus)

GLP-1 receptor agonists, especially in combination with metformin, emerged as the most effective interventions for reducing body weight and BMI, with GLP-1 alone also significantly reducing waist circumference

Rogan's choice of secretagogues over direct HGH reflects this risk-benefit calculus

Hinson JA, Monks TJ, Hong M, Highet RJ, Pohl LR