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Lonardo A, Ballestri S
Exendin-4 (Ex-4), another GLP-1RA that is homologous to commercially available exenatide, ameliorated IR in primary neurons through insulin receptor substrate-1 (IRS-1), AKT, and glycogen synthase kinase-3 (GSK-3) pathways
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However, little attention has been given to the potential that other types of muscle, such as cardiac muscle, may also be lost in response to GLP-1RAs. The researchers emphasized that they are uncertain whether Ozempic or Wegovy use actually causes cardiac atrophy in humans specifically
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