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If you have kept the vial at 2 to 8 C the entire time (no fridge failures, no transit exposures, no freezer accidents), the manufacturer stands behind the labeled shelf life
If you experienced anaphylaxis, angioedema, or other serious allergic reactions during previous exposure, do not attempt rechallenge
This phenomenon, sometimes referred to as early worsening of diabetic retinopathy, appears to be related to the magnitude and speed of glucose lowering rather than a direct effect of the medication
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