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While surveying the literature in preparation of this manuscript we have also noticed and reported an increasing interest in the role that GSTs play in neurodegeneration, where isozymes belonging to the family may be either up-regulated, mutated or absent, according to the different diseases

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In particular, the positive impact on maximal effect (E max ) in this assay format significantly improves the chances of identifying weak agonists during high-throughput screening (HTS)

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