If GLP-1 therapy is considered appropriate, close monitoring for symptom changes is essential
As discussed later, the causes of neuronal death in ALS/FTLD are also unknown and are being investigated in animal models, with studies supporting a role for oxidative damage, excitotoxicity, and apoptosis [46, 110, 132, 170]
There are patients that didn't lose weight on these medications and there are patients that lost more than the average, and that is sometimes forgotten in a lot of trending media posts. Some patients respond strongly even at the lowest approved dose
The human GLP-1R has an unusually high activation barrier and is essentially silent in the absence of an agonist ligand, relative to other class B GPCRs (e.g
Additionally, these glioma cells exhibit DNA damage when treated with metformin or simvastatin alone (Fig