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Many people either taper, maintain, or restart with a clinician-led plan and lifestyle support

[14] Patients without baseline hepatic concerns typically do not require routine LFT monitoring beyond what is standard for diabetes or obesity management

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As a small molecule synthesized through conventional organic chemistry, orforglipron can be produced at a fraction of the cost of peptide-based GLP-1 agonists, which require complex solid-phase peptide synthesis, extensive purification, and cold-chain distribution