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Concurrent administration of pyridoxine with these medications has been reported to lower their therapeutic levels, so monitoring and dosage adjustments of the anticonvulsant might be required if high-dose vitamin B is given

Considering that ASD is stable to P450 enzymes, characterized by high solubility, low permeability and classified as BCS 3 compound, the low bioavailability could be attributed to the poor gastrointestinal absorption rather than to potent first pass metabolism

Cell and tissue research , 377 (2), 153-159

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There is, however, a possibility that BPC 157 may not be right for everyone