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Monoamines are highly unstable, chemically reactive molecules , any unbound cytoplasmic neurotransmitter is highly prone to auto-oxidation in the cytosol (Lohr et al., 2014

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They approach what bariatric surgery produces, which is roughly 25 to 30% weight reduction, and they do so with a weekly subcutaneous injection rather than a surgical procedure

[7] The US Food and Drug Administration (FDA) approved dulaglutide with a Risk Evaluation and Mitigation Strategy (REMS), [7] and granted the approval of Trulicity to Eli Lilly and Company

Clinical data suggests dual therapy may offer additive glucose-lowering effects in specific type 2 diabetes cases, though individual response varies significantly