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After four weeks, the dose can be slowly increased every 4 weeks by 2.5 mg dosage increments up to a maximum of 15 mg weekly

31 The second study enrolled 60 patients with varying degrees of renal impairment and administered 5 mg of oral semaglutide daily for the first 5 days, followed by a 10-mg dose once daily for the remaining 5 days of the study

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The relevant question is not "did GLP-1 increase by a percentage" but "did GLP-1 increase to a level that produces clinically meaningful effects on appetite and weight?" Consider this comparison

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