Tornehave D, Kristensen P, Romer J, Knudsen LB, and Heller RS
What the preclinical signal tells us One of the clearest historical preclinical signals comes from a rat study indexed in PubMed
It is posited that glutathione suppositories could be useful for patients who may have difficulty with oral supplementation due to gastrointestinal absorption issues, as the rectal route bypasses the gastrointestinal tract
Burwinkel B, Kreuder J, Schweitzer S, Vorgerd M, Gempel K, Gerbitz KD, Kilimann MW: Carnitine transporter OCTN2 mutations in systemic primary carnitine deficiency: a novel Arg169Gln mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality
It also boosts the activity of glutathione by regenerating its oxidized form, ensuring its availability for cellular detoxification