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Tirzepatide accumulates with repeated weekly administration until it reaches steady state, so each dose adds to drug left over from the week before rather than building from a low baseline

[11] Anecdotal reports suggest it may be more effective at lower doses than semaglutide for inflammation and food noise, but we lack the specific low-dose clinical trials to back this up

Questions to raise at an initial consultation: What is a realistic expected duration of treatment given this specific history and these goals

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Third, MR estimates, although less confounded, are less precise than conventional observational studies, because the genetic variants only explain a small proportion of the variance in exposure [38]