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Through EMT, epithelial cells lose cell polarity, connections to the basement membrane and other epithelial phenotypes, and gain mesenchymal phenotypes such as increased migratory and invasive abilities, anti-apoptotic features and the capacity to degrade the extracellular matrix (79)

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The non-coded amino acid residues incorporated at positions 2, 20, and 13 provide resistance to enzymatic degradation while maintaining receptor-binding affinity across all three target receptors

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