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In accordance with the glutathione activator hypothesis, only positively charged amino acids replace Lys105 in enzymatically active glutaredoxins, whereas in inactive isoforms and other members of the thioredoxin superfamily the activator candidate is often separated from the catalytic cysteine residue in the primary sequence or is replaced by uncharged residues 3,11,12 (Fig
doi: 10.1016/j.ejphar.2020.173546 270 TangZ.SongT.SuH.-X
Fission, mediated by dynamin-related protein 1 (DRP1), facilitates mitochondrial fragmentation, often associated with apoptosis or mitophagy, while fusion, controlled by mitofusins (MFN1/2) and optic atrophy protein 1 (OPA1), promotes mitochondrial interconnectivity and bioenergetic stability (Zhang et al., 2018)
c-Myc is a transcription factor involved in diverse human malignant tumors 129,130
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