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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

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Many patients read, work on their phone, or simply relax while receiving their drip

KPV's published research has substantial focus on intestinal inflammation models, making KLOW potentially relevant for gastrointestinal research questions in ways GLOW isn't