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In any case, mounting evidence through germ-free (GF) rodents [80], microbiota transplant studies [81, 82], and microbiota-targeted interventions such as those mediated by dietary supplementation or antibiotics treatment [83, 84] highlight the importance of the gut microbiota composition for adult hippocampal neurogenesis (reviewed in [85])

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6g), low plasma clearance (0.26 mL/min/kg), and C max of 89.4 g/mL (48.5 M molar concentration), which was 60-fold excess of 2012 plasma concentration compared to required in vitro therapeutic levels (focal adhesion IC 50 = 0.8 M)

None of these substitute for medication, but they have legitimate places in a broader metabolic health plan

Notably, patients carrying the apolipoprotein E epsilon-4 allele, the strongest genetic risk factor for Alzheimer disease, showed the highest BDNF responses to cerebrolysin treatment