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Goals of diabetes management Reduce the risk of complications from cardiovascular disease, kidney disease, or overweight/obesity Control blood glucose to reduce microvascular complications (e.g., retinopathy and neuropathy) For patients with established atherosclerotic cardiovascular disease (ASCVD), high risk for ASCVD, chronic kidney disease, heart failure, overweight/obesity, or metabolic dysfunction-associated steatotic liver disease, starting with or adding a sodium-glucose co-transporter 2 (SGLT-2) inhibitor or a glucagon-like peptide-1 (GLP-1) receptor agonist (RA)-containing medication may be the best choice

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As an insulinotropic hormone, GLP-1 plays a substantial role in the regulation of glucose homeostasis, not only in the periphery but also in the central nervous system [90]

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