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By engineering the C-terminal portion of Exendin-4 to include amino acid sequences from glucagon in addition to a fatty acid side chain, Evers and colleagues developed a potent balanced co-agonist peptide 14

Reduces major adverse cardiovascular events via direct cardiac and endothelial receptor signalling

Increasing doses too quickly or without guidance can undermine safety and reduce the likelihood of sustained success

Compared with non-diabetic plaques, diabetic plaques had more inflammation and oxidative stress, along with a lower sirtuin (SIRT)6 expression and less interstitial collagen content

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