Some individuals experience apparent tolerance loss that actually reflects changes in compounded peptide potency
PMID: 15 HuangfuLLiRHuangYWangS
To solve the challenge, numerous researchers devote to exploring the mechanism of PIPN, which are principally implicated in transporter overexpression (Sprowl et al., 2013), ROS upregulation (Leo et al., 2020), ion channel dysfunction (Descoeur et al., 2011), transient receptor potential (TRP) overexpression (Chukyo et al., 2018), inflammatory response (Janes et al., 2015), and so on
Same molecule, but a completely different delivery leading to different results
Patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy during treatment