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Furthermore, the DPP-IV product, GLP-1(9-36) NH2 , is trimmed into GLP-1(28-36) NH2 and GLP-1(32-36) NH2 by another ubiquitous protease, known as NEP24.11, CD10 or also Neprilysin among other names (119, 120)

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Das Auftreten von unerwarteten schwerwiegenden Produktwirkungen (USADEs) knnte darauf hindeuten, dass die klinische Prfung fr die Probanden ein hheres Schadensrisiko darstellt, als zuvor erwartet wurde, und kann Konsequenzen fr die Fortfhrung der Studie haben (MDCG 2020-10 und ISO14155:2011/AC2011)

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