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Human growth hormone (HGH) plays a central role in body composition, metabolism, muscle mass, fat loss, and cellular repair
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Additionally, IGF-1 enhances expression and activity of enzymes involved in fatty acid metabolism, including carnitine palmitoyltransferase-1, the rate-limiting enzyme for fatty acid entry into mitochondria for oxidation
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To explore the substrate-binding sites in both the dimeric and stacked assemblies, we superimposed the COP1 WD40 with Trib1 (homolog of Drosophila tribbles), which are adaptors for C/EBP degradation (PDB: 5IGQ) onto the individual COP1 WD40 domain in these two states of structures (Supplementary Fig
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