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Nouwen A et al (2010) Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis

This ingredient is often compared to hyaluronic acid or glycerin

This structural optimization led to the identification of Compound 32 , a highly potent indane derivative with improved PDE1B inhibitory activity (PDE1B IC 50 : 2.4 nM) (Figure 10)