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Last month, the FDA updated the label for Ozempic to warn of the potential for intestinal blockage, which is already listed as a side-effect for Wegovy and Mounjaro
But at the doses used, the net effect on blood sugar is positive because the GLP-1 and GIP activity dominates, and the glucagon activation primarily drives fat burning rather than glucose release
Mol Syst Biol 6:392 Bleau C, Karelis AD, St-Pierre DH, Lamontagne L (2015) Crosstalk between intestinal microbiota, adipose tissue and skeletal muscle as an early event in systemic low-grade inflammation and the development of obesity and diabetes
We naturally produce glutathione, though factors like aging, stress, poor diet, and environmental toxins can deplete our glutathione levels over time