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Months 6 to 12: Continued weight loss and sustained metabolic improvement

Bioregulator peptides

Accessed 27 Dec 2023 Finan B, Ma T, Ottaway N et al (2013) Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

With significant or rapid weight loss, particularly when driven by GLP-1 drugs, several mechanisms converge: Loss of underlying fat volume removes structural support Collagen and elastin fibres become stretched and fragmented Speed of weight loss outpaces skin contraction While some rebound occurs naturally, significant laxity can be permanent, especially after large weight reductions

Wang XH, Li L, Holscher C, Pan YF, Chen XR, Qi JS