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The injection site (abdomen, thigh, or upper arm) does not significantly affect nausea, though rotating sites prevents injection-site reactions

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For instance, macrophages differentiate into different subtypes, participate in synovial inflammatory responses, and exacerbate cartilage damage by releasing inflammatory mediators (such as IL-1,TNF-) and proteases (such as MMPs,ADAMTs) ( At the same time, the differentiation of immune cells is influenced by the joint microenvironment

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