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In patients with HFpEF, GLP-1RA significantly reduced the LV mass (WMD: -8.6 g
Nonetheless, converting these laboratory achievements into reliable clinical results continues to pose difficulties
It is synthesized as a proreceptor that is cleaved into alpha and beta chains and assembled into a covalent heterotetramer, two alpha subunits and two beta subunits held together by disulfide bonds, which sits in the membrane as a preformed dimer even in the absence of ligand
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