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While these highly reactive species are essential for cellular survival, excessive amounts can inflict damage on various cellular organelles

Arfsten DP, Johnson EW, Thitoff AR, Jung AE, Wilfong ER, Lohrke SM, et al

doi: 10.4161/gmic.22156 95

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Unless there is clear evidence of primary bladder pathology (e.g., small capacity under anesthesia, Hunner lesions), patients should have a multidisciplinary evaluation including assessment for neuropathic pain and psychological profile