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Of note, the commercial Iscoves Modified Dulbeccos Medium (IMDM) and Serum Free Expansion Medium (SFEM), which were used as the basal medium for erythroblast cultures, contain a supraphysiological concentration of cystine at 292 M as compared to physiological plasma concentration of 4075 M cysteine in SCD patients, which decreased further to 3060 M during vaso-occlusive pain episodes 36
Resist the temptation to increase your dose on your own because you think 'more is better.' That's a direct path to unnecessary and unpleasant side effects
Adequate sleep duration and quality appear essential for metabolic health
The specific mechanism warrants further exploration
Still very manageable
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